Towards the end of the 6th century B.C. The Persians under their King Darius, had dominated the Greek cities in Asia Minor. Kalymnos as well as Kos were forced to pay a heavy tribute to Darius
and became satellite states of his empire. Both islands however refused to take part in the Persian war against the rest of Greece which was still liberated. After the defeat of the Persians in 480 B.C. at the naval battle of Salamina and the total destruction of the Persian fleet at the Mykalis pass between the island of Samos and Asia Minor (479B.C.) the Kalymnians expelled the Persian guards from their shores and thus rid themselves of the Persian yoke.